Publications

Tropisetron enhances recognition memory in ovariectomized female rats.

Faculty Author(s): Maswood, Sharmin
Student Author(s): Hassell, Joel
Department: BIOL
Publication: Behavioural Pharmacology
Year: 2020
Abstract: The present study evaluated the acute effects of the 5-HT₃ receptor antagonist, tropisetron, on recognition memory in ovariectomized adult female rats. The non-spatial novel object recognition task was used to assess recognition memory. In this task, ovariectomized rats explored two identical objects during Trial 1. Immediately after Trial 1, rats were primed either with oil, 250 µg progesterone, 20 µg of estrogen, or 20 µg of estrogen + 250 µg progesterone. Four hours later, the test trial (Trial 2) was initiated. Thirty minutes before Trial 2, rats were injected intraperitoneally with either saline, 1.5 or 2.5 mg/Kg tropisetron. During Trial 2, one arm of the T maze contained an object from Trial 1 (familiar or previously encountered), and a new object (novel) was introduced into the other arm. Exploration times with the novel and familiar objects were recorded and data were converted to percent time spent with the novel object. In oil-primed ovariectomized female rats, treatment with 2.5 mg/Kg tropisetron significantly increased percent time with the novel object. Hormonal-priming with estrogen, progesterone, or estrogen + progesterone did not further accentuate the effects of tropisetron. These results suggest that although tropisetron, estrogen, and progesterone all act as antagonists at the 5-HT₃ receptors and blocking 5-HT₃ receptors enhances cognition, there appears to be no interaction between tropisetron and these hormones on object recognition. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
Link: Tropisetron enhances recognition memory in ovariectomized female rats.